b'Made-to-measure eye care and evaluate the effectiveness of the new treatments were developing. Theres a revolution coming. We have moreAdvances in informatics to manageGenomics and imaging are producing information at our fingertips than ever before,and analyse all that data moreextremely large, detailed datasets, efficiently will help us apply ourso were going to need advanced which we could use to tailor diagnosis andnewfound knowledge to the clinicinformatics tools to make sense of all treatment individually to each patient. But to and translate it into real benefits that data in a way that leads to new make personalised medicine a reality, we first for patients. treatments for patients.need to invest in three key areas of research. Together, research in these three areas will help us better understandDr Nikolas PontikosGenomics (the study of our genesus to new treatments. New imagingeach patients particular condition, and DNA) will help us understandtechniques and vision tests will helpthe causes underlying it, and which which genetic changes cause orus understand how those genetictreatments are most likely to be contribute to eye diseases and leadchanges are affecting our bodieseffective for them.Understanding our genetic codeTurning knowledge into treatmentsGenomics is the basis of personalisedhow those mistakes lead to sight medicine. Exploring the genetic basisloss. That makes it hard to treat:Theres a catch. Many differentAdvances in genomics and imagingdiagnose patients faster and more of diseases helps us understand howcurrently the only treatment is genetic spelling mistakes can allhave led to fantastic new treatmentsprecisely, enabling them to access they lead to sight loss and find newa corneal transplant. cause (or contribute to) the same but they only work in patientsrevolutionary new treatments.ways to treat them. Dr Alice Davidson is working to finddisease. That means that most next- who have a specific genetic profile,The more genetic and imaging data Take Fuchs dystrophy as an example,and explain those genetic spellinggeneration treatments wont workwhich makes things rather difficultwe collect, the more new treatments where water builds up in the corneamistakes. Shes hoping that herin every patientonly in peoplefor doctors.we will be able todevelop based on of the eye, causing swelling, loss ofwork will lead to new, non-surgicalwho have a specific genetic changeDr Nikolas Pontikos is on the case.these. However it will also become vision or even total blindness. Itstreatments that prevent peoplecausing their condition.Hes working on a new tool calledincreasingly complicated to manage a genetic disease, so its caused bylosing their sight to this disease inFor example, over 1 in 3,000 peopleEye2Gene, which uses artificialand analyse these growing amounts spelling mistakes in particular genesthe first place, rather than relying in the UK have an inherited retinalintelligence to combine a patientsof data efficiently. Informatics toolsbut we dont fully understandon transplants to restore it. disease. Its the most common causesymptoms, pictures of their eyes andlike Eye2Gene will therefore be critical of blindness in young people in the UK,their genetic data to predict whichin enabling researchers and doctors and can be caused by many differenttreatments will work best for them.to translate our advancing knowledge genetic changes (spelling mistakes).Hes hoping it will help doctorsinto real benefit for patients.Seeing whats going wrongIn order to fully understand theThese images will help Tessa explore effect of genetic changes, wehow our brains learn to see, and need to map them onto physicalhow different genetic changesInvesting in these three pillarschanges in our eyes, in our brains ormight lead to inherited eye diseasesThese three fields - genomic medicine, imaging andpatient care. They are the pillars of personalised elsewhere in our bodies. That meansin children. Tessas new approachinformaticsare moving ahead at incredible speed,medicine, and they support one anotherso we must we need more advanced imagingcan also be used as a state-of- and together they are set to reveal revolutionary newcontinue to make progress in all three areas to realise techniques to find and explore them. the-art vision test for very youngtreatments and transform the way the NHS deliversour goal of offering patients truly personalised care.Its a challenge that Dr Tessa Dekkerchildren, so shes working with other from UCLs Child Vision Lab faces onresearchers to give them a more a daily basis. Shes investigating howcomplete picture of how well their vision develops in children - but younew treatments for inherited eyeAll three researchers mentioned in this article are cant shine a light into the brain, andconditions work in patients. supported by Moorfields Eye Charity through our reading charts dont work so well forIts probably one of the most important awards in mycareer development awards. Special thanks to our one year olds! Thats why we awardedentire career, because it will allow me to consolidate mydonors for their generous support in helping us her funding to create a brand newown independent research programme and lab at one ofto invest in future leaders and retain exceptional approach, using cutting-edge imagingthe best places in the world. talent in vision research.techniques to see whats going on inside the brains of young children.Dr Tessa Dekker4|Visibility Visibility|5'